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Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy

Authors :
Andre Kakinoki Teng
Eduardo Jorge Duque
Shirley Ferraz Crispilho
Wagner Domingues
Vanda Jorgetti
Luciene M. dos Reis
Rosilene M. Elias
Rosa Maria Affonso Moysés
Source :
Brazilian Journal of Nephrology, Vol 46, Iss 3 (2024)
Publication Year :
2024
Publisher :
Sociedade Brasileira de Nefrologia, 2024.

Abstract

Abstract Introduction: Secondary hyperparathyroidism (SHPT) is one of the causes for inflammation in CKD. We assessed the impact of parathyroidectomy (PTX) on neutrophil-to-lymphocyte (N/L) and platelet-to-lymphocyte (P/L) ratios in SHPT patients. Methods: A total of 118 patients [hemodialysis (HD, n = 81), and transplant recipients (TX, n = 37)] undergoing PTX between 2015 and 2021 were analyzed. Results: There was a significant reduction in calcium and PTH levels in both groups, in addition to an increase in vitamin D. In the HD group, PTX did not alter N/L and P/L ratios. In the TX group, there was a reduction in N/L and P/L ratios followed by a significant increase in total lymphocyte count. Conclusion: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.

Details

Language :
English, Portuguese
ISSN :
21758239
Volume :
46
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Brazilian Journal of Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.f0591c94a9294d29a389f99d5d77a76f
Document Type :
article
Full Text :
https://doi.org/10.1590/2175-8239-jbn-2023-0175en