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Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment
- Source :
- Ciência e Técnica Vitivinícola, Vol 34, Iss 2, Pp 115-122 (2019)
- Publication Year :
- 2019
- Publisher :
- EDP Sciences, 2019.
-
Abstract
- The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swimming test (FST). Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosteronetreated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.
- Subjects :
- depressive behavior
polyphenols
red wine
Plant culture
SB1-1110
Subjects
Details
- Language :
- English, Portuguese
- ISSN :
- 24163953
- Volume :
- 34
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Ciência e Técnica Vitivinícola
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bfdce6a5d4f15a68330d8ef44fa10
- Document Type :
- article
- Full Text :
- https://doi.org/10.1051/ctv/201934020115