Back to Search Start Over

Immune thrombocytopenia: literature review

Authors :
S. G. Zakharov
Source :
Онкогематология, Vol 19, Iss 3, Pp 34-44 (2024)
Publication Year :
2024
Publisher :
ABV-press, 2024.

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a decrease in platelet count, which often leads to bleeding. Evidence suggests that low platelet counts in ITP are the result of multiple factors, including impaired thrombocytopoiesis and changes in the immune response leading to platelet destruction. ITP is a heterogeneous disease with a course that is difficult to predict. In a significant number of cases, ITP becomes chronic, requiring long-term maintenance treatment, which leads to an increased risk of hemorrhagic complications and a decrease in quality of life. A deeper understanding ofthe etiology and pathogenesis ofthis disease makesit possible to identify potentialtherapeutic targets for the development of new effective treatments. This review summarizes recent advances in understanding the ITP pathophysiology, evaluating current therapeutic strategies and methods for predicting therapy response.

Details

Language :
Russian
ISSN :
18188346 and 24134023
Volume :
19
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Онкогематология
Publication Type :
Academic Journal
Accession number :
edsdoj.bfc3a5276b034fba847d3ad99247c4fc
Document Type :
article
Full Text :
https://doi.org/10.17650/1818-8346-2024-19-3-34-44