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Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project
- Source :
- Preventive Medicine Reports, Vol 26, Iss , Pp 101700- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (
Details
- Language :
- English
- ISSN :
- 22113355
- Volume :
- 26
- Issue :
- 101700-
- Database :
- Directory of Open Access Journals
- Journal :
- Preventive Medicine Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bf8583d5cb274094afa82dd1d7e0e0d0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.pmedr.2022.101700