Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease

Pelin Uysal,1 Gonul Simsek,2 Sinem Durmus,3 Volkan Sozer,4 Hulya Aksan,5 Sibel Yurt,6 Caglar Cuhadaroglu,1 Filiz Kosar,6 Remise Gelisgen,3 Hafize Uzun3 1Department of Chest Diseases, Faculty of Medicine, Mehmet Ali Aydinlar University, Atakent Hospital, Istanbul, Turkey; 2Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; 3Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; 4Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey; 5Deparment of Biochemistry, Faculty of Medicine, Halic University, İstanbul, Turkey; 6Clinic of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey Background: Antimicrobial peptides are effectors of host defence against infection and inflammation and can encourage wound repair. Objectives: The objectives of this study were to investigate the plasma antimicrobial peptide LL-37 and nuclear factor-kappaB (NF-κB) levels in patients with stable COPD compared with a control group and to highlight their importance in immune inflammation. Methods: One hundred and thirty-eight stable COPD patients and 33 control subjects were enrolled in the study. The COPD patients were classified into four groups based on FEV1 (groups I–IV) and also divided into “low-risk and high-risk” groups (groups A–B [low risk], C–D [high risk]). Results: Plasma LL-37 levels were significantly lower while plasma NF-κB levels of the COPD patients were significantly higher than those of the control subjects (P