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Effects of Olea oleaster leaf extract and purified oleuropein on ethanol-induced gastric ulcer in male Wistar rats
- Source :
- Iranian Journal of Basic Medical Sciences, Vol 27, Iss 8, Pp 996-1004 (2024)
- Publication Year :
- 2024
- Publisher :
- Mashhad University of Medical Sciences, 2024.
-
Abstract
- Objective(s): Evaluating the effect of fresh Oleaster leaf extract (OLE) and purified oleuropein (OLR) on ethanol-induced gastric ulcers in rats. HPLC analysis demonstrates the presence of various polyphenol compounds such as ligstroside, luteolin derivative, oleuropein, and comselogoside. Materials and Methods: Gastric ulcer was induced by administration of ethanol by the gastric gavage route. The olive leaf extract was analyzed by HPLC-PDA-ESI-MS, and OLR was purified. These two compounds were given 2 hr before gastric ulcer induction by ethanol.Results: This study verified that OLE and purified OLR protect from ethanol-induced gastric ulceration and damage, evidenced by the significant decrease in gastric ulcer urea (by 74 and 58% respectively) and stomach mucus content (by 169 and 87% respectively). In addition, the ulcer index (UI) and curative index (CI) levels in the stomach of the rats treated with this supplement were also suppressed by 55 and 46%, respectively. OLE and OLR also decreased the gastric myeloperoxidase (MPO) activity and ameliorated the Nitric oxide (NO) content. OLE and OL also ingestion suppressed gastric tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6) rates. Macroscopic and histological findings revealed that OLE and OLR protect from gastric hemorrhage, severe disruption of the gastric mucosa, and neutrophil infiltration.Conclusion: Overall, the findings demonstrate that OLE and OLR have both promising potential with regard to the inhibition of gastric hemorrhage and lesions.
- Subjects :
- inflammation
nitric oxide
olea oleaster
oleuropein
ulcer
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20083866 and 20083874
- Volume :
- 27
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Journal of Basic Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bf22d2d4f52f466c8fe3b3454578535e
- Document Type :
- article
- Full Text :
- https://doi.org/10.22038/ijbms.2024.76135.16474