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Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease

Authors :
Nicoletta Bianchi
Luisa Doneda
Luca Elli
Cristian Taccioli
Valentina Vaira
Alice Scricciolo
Vincenza Lombardo
Anna Terrazzan
Patrizia Colapietro
Leonardo Terranova
Carlo Bergamini
Maurizio Vecchi
Lucia Scaramella
Nicoletta Nandi
Leda Roncoroni
Source :
Biomedicines, Vol 10, Iss 6, p 1408 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell–cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.bf219958d57449cb8c5c1bc011b72b76
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10061408