Development of a potent embryonic chick lens model for studying congenital cataracts in vivo

Li et al. report an embryonic chick lens model to study the onset of congenital cataracts. By injecting recombinant retrovirus containing mutants that cause congenital cataract in lumen of embryonic chick lens, they show that their model exhibits cataract lens closely mimicking characteristics of human congenital cataracts.