Back to Search Start Over

Mortality in Severe Antibody Deficiencies Patients during the First Two Years of the COVID-19 Pandemic: Vaccination and Monoclonal Antibodies Efficacy

Authors :
Cinzia Milito
Francesco Cinetto
Andrea Palladino
Giulia Garzi
Alessandra Punziano
Gianluca Lagnese
Riccardo Scarpa
Marcello Rattazzi
Anna Maria Pesce
Federica Pulvirenti
Giulia Di Napoli
Giuseppe Spadaro
Rita Carsetti
Isabella Quinti
Source :
Biomedicines, Vol 10, Iss 5, p 1026 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Patients with severely impaired antibody responses represent a group at-risk in the SARS-CoV-2 pandemic due to the lack of Spike-specific neutralizing antibodies. The main objective of this paper was to assess, by a longitudinal prospective study, COVID-19 infection and mortality rates, and disease severity in the first two years of the pandemic in a cohort of 471 Primary Antibody Defects adult patients. As secondary endpoints, we compared SARS-CoV-2 annual mortality rate to that observed over a 10-year follow-up in the same cohort, and we assessed the impact of interventions done in the second year, vaccination and anti-SARS-CoV-2 monoclonal antibodies administration on the disease outcome. Forty-one and 84 patients were infected during the first and the second year, respectively. Despite a higher infection and reinfection rate, and a higher COVID-19-related mortality rate compared to the Italian population, the pandemic did not modify the annual mortality rate for any cause in our cohort compared to that registered over the last ten years in the same cohort. PADs patients who died from COVID-19 had an underlying end-stage lung disease. We showed a beneficial effect of MoAbs administration on the likelihood of hospitalization and development of severe disease. In conclusion, COVID-19 did not cause excess mortality in Severe Antibody Deficiencies.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.beef48585b044a0b93cf70b8016c20cf
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10051026