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Continuous Flow Glycolipid Synthesis Using a Packed Bed Reactor

Authors :
Rebecca Hollenbach
Delphine Muller
André Delavault
Christoph Syldatk
Source :
Catalysts, Vol 12, Iss 5, p 551 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Glycolipids are a class of biodegradable biosurfactants that are non-toxic and based on renewables, making them a sustainable alternative to petrochemical surfactants. Enzymatic synthesis allows a tailor-made production of these versatile compounds using sugar and fatty acid building blocks with rationalized structures for targeted applications. Therefore, glycolipids can be comprehensively designed to outcompete conventional surfactants regarding their physicochemical properties. However, enzymatic glycolipid processes are struggling with both sugars and fatty acid solubilities in reaction media. Thus, continuous flow processes represent a powerful tool in designing efficient syntheses of sugar esters. In this study, a continuous enzymatic glycolipid production catalyzed by Novozyme 435® is presented as an unprecedented concept. A biphasic aqueous–organic system was investigated, allowing for the simultaneous solubilization of sugars and fatty acids. Owing to phase separation, the remaining non-acylated glucose was easily separated from the product stream and was refed to the reactor forming a closed-loop system. Productivity in the continuous process was higher compared to a batch one, with space–time yields of up to 1228 ± 65 µmol/L/h. A temperature of 70 °C resulted in the highest glucose-6-O-decanoate concentration in the Packed Bed Reactor (PBR). Consequently, the design of a continuous biocatalytic production is a step towards a more competitive glycolipid synthesis in the aim for industrialization.

Details

Language :
English
ISSN :
20734344
Volume :
12
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Catalysts
Publication Type :
Academic Journal
Accession number :
edsdoj.bed5b48726914f23b28f0eda415a2d8d
Document Type :
article
Full Text :
https://doi.org/10.3390/catal12050551