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Deciphering multi-way interactions in the human genome

Authors :
Gabrielle A. Dotson
Can Chen
Stephen Lindsly
Anthony Cicalo
Sam Dilworth
Charles Ryan
Sivakumar Jeyarajan
Walter Meixner
Cooper Stansbury
Joshua Pickard
Nicholas Beckloff
Amit Surana
Max Wicha
Lindsey A. Muir
Indika Rajapakse
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Mapping higher order chromatin architecture is important. Here the authors use long sequencing reads to map genome-wide multi-way contacts and investigate higher order chromatin organisation; they use hypergraph theory for data representation and analysis, and apply this to different cell types.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.be92af01853349e7b49afa2d6e1da02d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-32980-z