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MYC overexpression but not MYC/BCL2 double expression predicts survival in bulky mass diffuse large B‐cell lymphoma patients

Authors :
Yanjie Wang
Donglin Liu
Xudong Zhang
Mingzhi Zhang
Shenglei Li
Xiaoyan Feng
Meng Dong
Shanshan Ma
Siyu Qian
Zeyuan Wang
Yue Zhang
Pengyuan Wang
Shuhao Mei
Qingjiang Chen
Source :
Cancer Medicine, Vol 12, Iss 18, Pp 18568-18577 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Purpose The prognostic factors for diffuse large B‐cell lymphoma (DLBCL) have been fully explored, but prognostic information for bulky mass DLBCL patients is limited. This study aimed to analyze the prognostic value of MYC protein expression and other biological parameters in bulky mass DLBCL patients. Methods We defined a bulky mass as a maximum tumor diameter ≥7.5 cm and studied 227 patients with de novo bulky mass DLBCL. Results In all patients with bulky mass DLBCL, the 1‐year and 3‐year OS rates were 72.7% and 57.1%, respectively, and the 1‐year and 3‐year PFS rates were 52.0% and 42.5%, respectively. The MYC overexpression group (n = 140) showed significantly worse overall survival (OS; p = 0.019) and progression‐free survival (PFS; p = 0.001) than the non‐MYC overexpression group (n = 87). Subgroup analyses demonstrated that the MYC overexpression group was associated with inferior OS and PFS in the subgroups with the International Prognostic Index score of 3–5 (OS: p = 0.011; PFS: p

Details

Language :
English
ISSN :
20457634
Volume :
12
Issue :
18
Database :
Directory of Open Access Journals
Journal :
Cancer Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.be22fde74ef450995b6d593634d26e4
Document Type :
article
Full Text :
https://doi.org/10.1002/cam4.6463