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Clinical markers for unfavorable course of multiple sclerosis

Authors :
Mariya S. Matrosova
Galina N. Belskaya
Vasiliy V. Bryukhov
Ekaterina V. Popova
Marina V. Krotenkova
Source :
Анналы клинической и экспериментальной неврологии, Vol 17, Iss 3, Pp 41-48 (2023)
Publication Year :
2023
Publisher :
Research Center of Neurology, 2023.

Abstract

Objective. To study possible clinical markers associated with the unfavorable course of multiple sclerosis and its transition to a progressive subtype. Materials and methods. This prospective study included healthy volunteers and patients with relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), primary progressive multiple sclerosis (PPMS). For a comprehensive clinical evaluation, the participants completed the Timed 25-Foot Walk Test (T25-FW), Nine-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Fatigue test, and MSProDiscuss questionnaires. Then we compared the results between the groups. Results. We found significant differences between the groups in regard to most of the tests. Furthermore, we proposed a composite clinical score (CCS) based on T25-FW, SDMT, and 9-HPT results (for both hands). Discussion. Our CCS can be a useful clinical tool to determine the most likely course of multiple sclerosis at a certain timepoint.

Details

Language :
English, Russian
ISSN :
20755473 and 24092533
Volume :
17
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Анналы клинической и экспериментальной неврологии
Publication Type :
Academic Journal
Accession number :
edsdoj.be1cbff2f3f494fa96b1266a53fbe6d
Document Type :
article
Full Text :
https://doi.org/10.54101/ACEN.2023.3.5