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Insights into organoid-based modeling of COVID-19 pathology

Authors :
Mohadese Hashem Boroojerdi
Tariq Al Jabry
Seyed Mohamad Javad Mirarefin
Halima Albalushi
Source :
Virology Journal, Vol 20, Iss 1, Pp 1-13 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.

Details

Language :
English
ISSN :
1743422X
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Virology Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.be11fa1498664ea5aae14b89f622c7b6
Document Type :
article
Full Text :
https://doi.org/10.1186/s12985-023-01996-2