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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Authors :
Fiona A. Hagenbeek
René Pool
Jenny van Dongen
Harmen H. M. Draisma
Jouke Jan Hottenga
Gonneke Willemsen
Abdel Abdellaoui
Iryna O. Fedko
Anouk den Braber
Pieter Jelle Visser
Eco J. C. N. de Geus
Ko Willems van Dijk
Aswin Verhoeven
H. Eka Suchiman
Marian Beekman
P. Eline Slagboom
Cornelia M. van Duijn
BBMRI Metabolomics Consortium
Amy C. Harms
Thomas Hankemeier
Meike Bartels
Michel G. Nivard
Dorret I. Boomsma
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Blood metabolite levels are under the influence of environmental and genetic factors. Here, Hagenbeek et al. perform heritability estimations for metabolite measures and determine the contribution of known metabolite loci to metabolite levels using data from 40 genome-wide association studies.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.bdd7a85c5d32461f9a054623f04904bd
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13770-6