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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
- Source :
- International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100094- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die Py correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die Py is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.
Details
- Language :
- English
- ISSN :
- 25901567
- Volume :
- 3
- Issue :
- 100094-
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Pharmaceutics: X
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bd84d15c992841bc9ce3e08aa00abd5c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ijpx.2021.100094