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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

Authors :
Gerrit Vreeman
Changquan Calvin Sun
Source :
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100094- (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die Py correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die Py is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.

Details

Language :
English
ISSN :
25901567
Volume :
3
Issue :
100094-
Database :
Directory of Open Access Journals
Journal :
International Journal of Pharmaceutics: X
Publication Type :
Academic Journal
Accession number :
edsdoj.bd84d15c992841bc9ce3e08aa00abd5c
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ijpx.2021.100094