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Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

Authors :
Michal Pardo
Svenja Offer
Elena Hartner
Sebastiano Di Bucchianico
Christoph Bisig
Stefanie Bauer
Jana Pantzke
Elias J. Zimmermann
Xin Cao
Stephanie Binder
Evelyn Kuhn
Anja Huber
Seongho Jeong
Uwe Käfer
Eric Schneider
Arunas Mesceriakovas
Jan Bendl
Ramona Brejcha
Angela Buchholz
Daniela Gat
Thorsten Hohaus
Narges Rastak
Erwin Karg
Gert Jakobi
Markus Kalberer
Tamara Kanashova
Yue Hu
Christoph Ogris
Annalisa Marsico
Fabian Theis
Tali Shalit
Thomas Gröger
Christopher P. Rüger
Sebastian Oeder
Jürgen Orasche
Andreas Paul
Till Ziehm
Zhi-Hui Zhang
Thomas Adam
Olli Sippula
Martin Sklorz
Jürgen Schnelle-Kreis
Hendryk Czech
Astrid Kiendler-Scharr
Ralf Zimmermann
Yinon Rudich
Source :
Environment International, Vol 166, Iss , Pp 107366- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities of soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) and SP coated with naphthalene SOA (SOANap-SP) in a human bronchial epithelial cell line (BEAS-2B) residing at the air–liquid interface. SOAβPin-SP mostly contained oxygenated aliphatic compounds from β-pinene photooxidation, whereas SOANap-SP contained a significant fraction of oxygenated aromatic products under similar conditions. Following exposure, genome-wide transcriptome responses showed an Nrf2 oxidative stress response, particularly for SOANap-SP. Other signaling pathways, such as redox signaling, inflammatory signaling, and the involvement of matrix metalloproteinase, were identified to have a stronger impact following exposure to SOANap-SP. SOANap-SP also induced a stronger genotoxicity response than that of SOAβPin-SP. This study elucidated the mechanisms that govern SOA toxicity and showed that, compared to SOAs derived from a typical biogenic precursor, SOAs from a typical anthropogenic precursor have higher toxicological potency, which was accompanied with the activation of varied cellular mechanisms, such as aryl hydrocarbon receptor. This can be attributed to the difference in chemical composition; specifically, the aromatic compounds in the naphthalene-derived SOA had higher cytotoxic potential than that of the β-pinene-derived SOA.

Details

Language :
English
ISSN :
01604120
Volume :
166
Issue :
107366-
Database :
Directory of Open Access Journals
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
edsdoj.bd48c19d14b74b3a80d1bdf5c378cd84
Document Type :
article
Full Text :
https://doi.org/10.1016/j.envint.2022.107366