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Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil

Authors :
Josilene R. Pinheiro
Esther C. dos Reis
Jéssica P. Farias
Mayanna M. C. Fogaça
Patrícia de S. da Silva
Itana Vivian R. Santana
Ana Luiza S. Rocha
Paloma O. Vidal
Rafael da C. Simões
Wilson B. Luiz
Alexander Birbrair
Renato S. de Aguiar
Renan P. de Souza
Vasco A. de C. Azevedo
Gepoliano Chaves
Aline Belmok
Ricardo Durães-Carvalho
Fernando L. Melo
Bergmann M. Ribeiro
Jaime Henrique Amorim
Source :
Viruses, Vol 14, Iss 10, p 2314 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients’ nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment.

Details

Language :
English
ISSN :
19994915
Volume :
14
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.bd11670a05c34c81a0d498bedbf1c141
Document Type :
article
Full Text :
https://doi.org/10.3390/v14102314