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Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles
- Source :
- Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 118-124 (2024)
- Publication Year :
- 2024
- Publisher :
- Beilstein-Institut, 2024.
-
Abstract
- A visible-light-promoted research protocol for constructing dihydropyrido[1,2-a]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl radicals. This method allows the efficient synthesis of various indole derivatives without the need of photocatalysts or transition-metal catalysts. Mechanism experiments indicate that the process involves a radical chain process initiated by the homolysis of Umemoto's reagent. This straightforward method enables a rapid access to heterocycles containing a trifluoromethyl group.
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 20
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Beilstein Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc89d3049be949deb518398f97606edf
- Document Type :
- article
- Full Text :
- https://doi.org/10.3762/bjoc.20.12