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Apolipoprotein E and PAI-1 gene polymorphisms and no association with arterial ischemic stroke and peripheral arterial disease manifestations
- Source :
- Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 54, Iss 3, Pp 138-145 (2018)
- Publication Year :
- 2018
- Publisher :
- Sociedade Brasileira de Patologia Clínica, 2018.
-
Abstract
- ABSTRACT Introduction: Arterial thrombosis is considered a multifactorial disease, resulting from the interaction of genetic and acquired risk factors. Objectives: The aim of this study was to investigate the presence of the polymorphism in inhibitor of plasminogen activator type 1 (PAI-1) and apolipoprotein E (ApoE) genes and its interactions with PAI-1 levels and lipids and apolipoprotein profiles, respectively, as well as the frequencies of these polymorphisms and their association with thrombosis. Methods: Ninety-seven patients [48 with arterial ischemic stroke (IS) and 49 with peripheral arterial disease (PAD)], treated at the hematology medical service were included in this study. Polymorphisms were also investigated in 201 control subjects. Polymorphisms were investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: For the PAI-1 polymorphism, there were 54.2% heterozygous (HT) genotypes and 12.5% homozygous (HM) genotypes in the patients' group, and 52.7% HT genotypes and 21.3% HM genotypes in the controls. For the ApoE polymorphism, there were 56.3% (ε3ε3), 6.3% (ε4ε4), 8.3% (ε2ε3), 4.2% (ε2ε4) and 24.9% (ε3ε4) in the patients, and 61.2% (ε3ε3), 4.5% (ε4ε4), 8% (ε2ε3), 4.5% (ε2ε4) and 21.8% (ε3ε4) in the controls. Conclusion: No significant difference was observed by comparing patients and controls. In this study, no association was found between the presence of the evaluated polymorphisms and the occurrence of thrombotic events.
- Subjects :
- thrombosis
apoenzymes
polymorphism genetic
Pathology
RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 16784774 and 16762444
- Volume :
- 54
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Jornal Brasileiro de Patologia e Medicina Laboratorial
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc7a2642e85c4f24a4d7a531cc8cb017
- Document Type :
- article
- Full Text :
- https://doi.org/10.5935/1676-2444.20180026