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Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy

Authors :
Isabelle Weinhofer
Paulus Rommer
Bettina Zierfuss
Patrick Altmann
Martha Foiani
Amanda Heslegrave
Henrik Zetterberg
Andreas Gleiss
Patricia L. Musolino
Yi Gong
Sonja Forss-Petter
Thomas Berger
Florian Eichler
Patrick Aubourg
Wolfgang Köhler
Johannes Berger
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

X-linked adrenoleukodystophy (X-ALD) is a highly variable, progressive neurodegenerative disorder. In this study, neurofilament light chain protein (NfL) was identified as a potential early distinguishing biomarker.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.bc793312378441c5a3bc5301eb2c1762
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22114-2