Back to Search
Start Over
dCas9 regulator to neutralize competition in CRISPRi circuits
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- CRISPRi allows for the simultaneous control of many genes, however the sgRNAs compete for binding to dCas9. Here the authors design a dCas9 concentration regulator to allow independent regulation of multiple genes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 77626575
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc77626575304f0082d2047b7dc45282
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-21772-6