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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation

Authors :
Nannan Guo
Na Li
Li Jia
Qinyue Jiang
Mette Schreurs
Vincent van Unen
Susana M. Chuva de Sousa Lopes
Alexandra A. Vloemans
Jeroen Eggermont
Boudewijn Lelieveldt
Frank J. T. Staal
Noel F. C. C. de Miranda
M. Fernanda Pascutti
Frits Koning
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The intestine is an important immunological organ in embryonic life, preparing the infant for the microbial colonization following birth. Here authors show that between gestational weeks 14 and 22, the human foetal intestine is first populated by myeloid and innate lymphoid cells, followed by the development of lymphoid cells and a wider range of proliferation-capable immune cell types.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.bc204bc2c6094dffa261d580b254f052
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-37052-4