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Macromolecular Nanocrystal Structural Analysis with Electron and X-Rays: A Comparative Review

Authors :
Krishna P. Khakurel
Borislav Angelov
Jakob Andreasson
Source :
Molecules, Vol 24, Iss 19, p 3490 (2019)
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Crystallography has long been the unrivaled method that can provide the atomistic structural models of macromolecules, using either X-rays or electrons as probes. The methodology has gone through several revolutionary periods, driven by the development of new sources, detectors, and other instrumentation. Novel sources of both X-ray and electrons are constantly emerging. The increase in brightness of these sources, complemented by the advanced detection techniques, has relaxed the traditionally strict need for large, high quality, crystals. Recent reports suggest high-quality diffraction datasets from crystals as small as a few hundreds of nanometers can be routinely obtained. This has resulted in the genesis of a new field of macromolecular nanocrystal crystallography. Here we will make a brief comparative review of this growing field focusing on the use of X-rays and electrons sources.

Details

Language :
English
ISSN :
14203049
Volume :
24
Issue :
19
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.bbbe3ffb33a54b989b8f7738907095b4
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules24193490