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Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study

Authors :
Larissa Nixdorf
Lukas Hartl
Stefanie Ströhl
Daniel Moritz Felsenreich
Magdalena Mairinger
Julia Jedamzik
Paula Richwien
Behrang Mozayani
Georg Semmler
Lorenz Balcar
Michael Schwarz
Mathias Jachs
Nina Dominik
Christoph Bichler
Michael Trauner
Mattias Mandorfer
Thomas Reiberger
Felix B. Langer
David Josef Maria Bauer
Gerhard Prager
Source :
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Publication Year :
2024
Publisher :
Nature Portfolio, 2024.

Abstract

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021–2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8% and MASH in 34.4% of patients. At M3 the median relative total weight loss (%TWL) was 20.1% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p

Details

Language :
English
ISSN :
20452322
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.bb5b5f12d8734c4fa7cf92b83afbf7ba
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-024-67415-w