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Differences in Clinical and Immunological Characteristics According to the Various Criteria for Tissue Eosinophilia in Chronic Rhinosinusitis With Nasal Polyps
- Source :
- Clinical and Experimental Otorhinolaryngology, Vol 16, Iss 4, Pp 359-368 (2023)
- Publication Year :
- 2023
- Publisher :
- Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2023.
-
Abstract
- Objectives Several criteria exist for classifying chronic rhinosinusitis with nasal polyps (CRSwNP) as eosinophilic or non-eosinophilic. This study attempted to evaluate several criteria for defining eosinophilic CRSwNP from clinical and immunological perspectives. Methods A cohort of 84 patients (73 patients with CRSwNP and 11 control patients) was retrospectively analyzed. Patients were divided into eosinophilic and non-eosinophilic CRSwNP based on four different criteria: eosinophils (EOS) accounting for more than 20% of the total inflammatory cells; ≥70 EOS per high-power field (HPF); >55 EOS/HPF; and ≥10 EOS/HPF. Preoperative clinical characteristics, the immunological profiles of 14 cytokines from nasal tissue, and postoperative outcomes were compared between eosinophilic and non-eosinophilic CRSwNP based on each criterion. These criteria were immunologically validated by using 14 cytokines to predict the performance of tissue eosinophilia with a random forest model. Results Patients with eosinophilic CRSwNP were significantly older when the criterion of ≥10 EOS/HPF or EOS >20% was used. The number of patients with aspirin intolerance was significantly higher in eosinophilic CRSwNP based on the criterion of EOS >20%. From an immunological perspective, non-type 2 inflammatory cytokines were significantly higher in non-eosinophilic CRSwNP with the criterion of EOS >20% of the total inflammatory cells. In addition, the criterion of EOS >20% of the total inflammatory cells resulted in the best prediction of eosinophilic CRSwNP, with an accuracy of 88.10% and area under the curve of 0.94. Conclusion Clinical and immunological characteristics were different between eosinophilic and non-eosinophilic CRSwNP depending on a variety of criteria, and the results of this study should be taken into account when choosing the criterion for defining eosinophilic CRSwNP and interpreting the data accordingly.
- Subjects :
- sinusitis
nasal polyp
eosinophils
classification
Medicine
Otorhinolaryngology
RF1-547
Subjects
Details
- Language :
- English
- ISSN :
- 19768710 and 20050720
- Volume :
- 16
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Experimental Otorhinolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bb50fa089fc4351ba2c74924c822cf5
- Document Type :
- article
- Full Text :
- https://doi.org/10.21053/ceo.2023.00542