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Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol
- Source :
- BJGP Open (2020)
- Publication Year :
- 2020
- Publisher :
- Royal College of General Practitioners, 2020.
-
Abstract
- Background: Clinical guidelines recommend specific targets for low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) for primary prevention of cardiovascular disease (CVD). Furthermore, individual variability in lipid response to statin therapy requires assessment of the association in diverse populations. Aim: To assess whether lower concentrations of LDL-C and non-HDL-C are associated with a reduced risk of major adverse cardiovascular events (MACE) in primary prevention of CVD. Design & setting: An international, new-user, cohort study will be undertaken. It will use data from three electronic health record databases from three global regions: Clinical Practice Research Datalink, UK; PREDICT-CVD, New Zealand (NZ); and the Clinical Data and Analysis Reporting System, Hong Kong (HK). Method: New statin users without a history of atherosclerotic CVD, heart failure, or chronic kidney disease, with baseline and follow-up lipid levels will be eligible for inclusion. Patients will be classified according to LDL-C (
Details
- Language :
- English
- ISSN :
- 23983795
- Database :
- Directory of Open Access Journals
- Journal :
- BJGP Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bb1ba69b8ce54256b1bf17242ac3fbb5
- Document Type :
- article
- Full Text :
- https://doi.org/10.3399/bjgpopen20X101127