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Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bb0fbe49441045209c09d3f5a07f28af
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19414-4