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MOLECULAR INVESTIGATION OF ANTI-DIABETIC EFFECT OF BALANITES AEGYPTIACA FRUITS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
- Source :
- Slovenian Veterinary Research, Vol 55, Iss 20-Suppl (2018)
- Publication Year :
- 2018
- Publisher :
- University of Ljubljana Press (Založba Univerze v Ljubljani), 2018.
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Abstract
- Balanites aegyptiaca (B. aegyptiaca) is an anti-diabetic medicinal plant traditionally used in Egyptian folk medicine as alternative therapy for the treatment of type 2 diabetes. No available studies revealed the mechanism(s) of the associated anti-diabetic effect especially at the molecular level. This study aimed to explore the possible molecular mechanism(s) that underline B. aegyptiaca fruits aqueous extract administration in diabetic and non-diabetic rats. Four equal groups (n=10) of albino rats were used. The prepared aqueous extract of B. aegyptiaca fruits was given orally (80 mg/kg body weight for 4 weeks) to normal control and streptozotocin (65 mg/kg BW, i. p.) -induced-diabetic rats. Administration of B. aegyptiaca fruits aqueous extract in diabetic rats significantly elevated the serum insulin (91%) and reduced serum glucose (54%), cholesterol (26%), triglycerides (16%) and LDL cholesterol (25%) compared to the diabetic control. Produced hypoglycemia in treated diabetic rats simultaneously accompanied at least by significant improving (p
Details
- Language :
- English, Slovenian
- ISSN :
- 15804003 and 23858761
- Volume :
- 55
- Issue :
- 20-Suppl
- Database :
- Directory of Open Access Journals
- Journal :
- Slovenian Veterinary Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bac18952e6524cc0ae4902f679ccc30e
- Document Type :
- article
- Full Text :
- https://doi.org/10.26873/SVR-638-2018