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Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway

Authors :
Shaona Li
Yexiang Xu
Simeng He
Xiangyun Li
Jia Shi
Bing Zhang
Youzhuang Zhu
Xiangkun Li
Yanting Wang
Cuicui Liu
Yang Ma
Shuan Dong
Jianbo Yu
Source :
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-18 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Purpose Endotoxin-induced acute lung injury (ALI) is a severe disease caused by an imbalanced host response to infection. It is necessary to explore novel mechanisms for the treatment of endotoxin-induced ALI. In endotoxin-induced ALI, tetramethylpyrazine (TMP) provides protection through anti-inflammatory, anti-apoptosis, and anti-pyroptosis effects. However, the mechanism of action of TMP in endotoxin-induced ALI remains unclear. Here, we aimed to determine whether TMP can protect the lungs by inhibiting Golgi stress via the Nrf2/HO-1 pathway. Methods and results Using lipopolysaccharide (LPS)-stimulated C57BL/6J mice and MLE12 alveolar epithelial cells, we observed that TMP pretreatment attenuated endotoxin-induced ALI. LPS + TMP group showed lesser lung pathological damage and a lower rate of apoptotic lung cells than LPS group. Moreover, LPS + TMP group also showed decreased levels of inflammatory factors and oxidative stress damage than LPS group (P

Details

Language :
English
ISSN :
14712466
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Pulmonary Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.baa7762ffdfd4ec78711a6d669e36a17
Document Type :
article
Full Text :
https://doi.org/10.1186/s12890-023-02585-3