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Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]
- Source :
- Wellcome Open Research, Vol 5 (2020)
- Publication Year :
- 2020
- Publisher :
- Wellcome, 2020.
-
Abstract
- Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P
Details
- Language :
- English
- ISSN :
- 2398502X and 59178078
- Volume :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Wellcome Open Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.ba907e3acc744e591780785445a64b1
- Document Type :
- article
- Full Text :
- https://doi.org/10.12688/wellcomeopenres.15846.1