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Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

Authors :
Antoni Soriano-Arandes
Marie Antoinette Frick
Milagros García López-Hortelano
Elena Sulleiro
Carlota Rodó
María Paz Sánchez-Seco
Marta Cabrera-Lafuente
Anna Suy
María De la Calle
Mar Santos
Eugenia Antolin
María del Carmen Viñuela
María Espiau
Ainara Salazar
Borja Guarch-Ibáñez
Ana Vázquez
Juan Navarro-Morón
José-Tomás Ramos-Amador
Andrea Martin-Nalda
Eva Dueñas
Daniel Blázquez-Gamero
Resurrección Reques-Cosme
Iciar Olabarrieta
Luis Prieto
Fernando De Ory
Claire Thorne
Thomas Byrne
Anthony E. Ades
Elisa Ruiz-Burga
Carlo Giaquinto
María José Mellado-Peña
Alfredo García-Alix
Elena Carreras
Pere Soler-Palacín
Source :
Pathogens, Vol 9, Iss 5, p 352 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.

Details

Language :
English
ISSN :
20760817
Volume :
9
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
edsdoj.ba481aa87944668ab533f66339fcfde
Document Type :
article
Full Text :
https://doi.org/10.3390/pathogens9050352