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Assessment of Amnesic Effect and the Depth of Hypnosis During Therapeutic Inhalation of Xenon-Oxygen Mixture

Authors :
I. A. Lisichenko
V. G. Gusarov
B. A. Teplykh
N. V. Chayanov
M. N. Zamyatin
Source :
Вестник анестезиологии и реаниматологии, Vol 19, Iss 5, Pp 19-27 (2022)
Publication Year :
2022
Publisher :
New Terra Publishing House, 2022.

Abstract

The current literature lacks data on the incidence of intraoperative awakening during xenon anesthesia. This could be due to amnesia preventing memories of the intraoperative awakening.The objective: to determine the concentration of xenon in the xenon-oxygen mixture, which causes amnesia for events during inhalation in 100% of patients, and to make correlations with the depth of hypnosis as per Kugler scale.Subjects and Methods: 34 patients with chronic neurogenic pain who received 111 20-minute inhalations with concentration of xenon up to 50% were included in the study. Amnesia evaluation, EEG monitoring, and pain assessment on a visual analog scale (VAS) were performed.Results. Amnesic effect developed in 100% of patients at xenon concentration of 45%. On inhalation of xenon at concentrations of up to 50%, EEG changes did not exceed D1 grade on Kugler scale. The decrease in bispectral index (BIS) did not reach the level of deep sedation (Me 96.2%) at xenon concentration of 50%. The decrease in pain on VAS was approximately 60%.Conclusions. Xenon inhalations cause transient congradic amnesia at concentrations of 45% or more. The accuracy of the BIS monitoring readings may be reduced when using xenon in a monovariant. Inhalations of xenon-oxygen mixture in concentrations up to 50% showed good analgesic properties in the framework of combined therapy of chronic pain syndrome.

Details

Language :
Russian
ISSN :
20785658 and 25418653
Volume :
19
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Вестник анестезиологии и реаниматологии
Publication Type :
Academic Journal
Accession number :
edsdoj.ba43d52092164bd0bab1f9515b1e65a4
Document Type :
article
Full Text :
https://doi.org/10.21292/2078-5658-2022-19-5-19-27