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ACUTE TOXICITY AND ANTINOCICEPTIVE ACTIVITY OF SAPONINS RICH FRACTION OF DIOSCOREA DELTOIDEA (WALL)
- Source :
- Khyber Medical University Journal, Vol 12, Iss 2, Pp 107-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Khyber Medical University, 2020.
-
Abstract
- OBJECTIVE: To evaluate the saponins rich fraction of Dioscorea deltoidea (D. deltoidea) for possible antinociceptive activity. METHODS: Saponins were extracted from the crude methanolic extract of D. deltoidea (Wall). Presence of saponins was confirmed through phytochemical screenings. Acute toxicity test was performed to determine safe dose range of the saponins rich fraction (n-butanol fraction) using balb C Mice. The saponins rich fraction was assessed for possible antinociceptive activity using acetic acid induced writhing method and hot plate method. Data was analyzed using Graph Pad Prism 6. ANOVA was used to determine the significance of test samples versus positive control at 95% CI with p
Details
- Language :
- English
- ISSN :
- 23052643 and 23052651
- Volume :
- 12
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Khyber Medical University Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.ba1feceb49b94e6e881e55589c86cef7
- Document Type :
- article
- Full Text :
- https://doi.org/10.35845/kmuj.2020.19787