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Exploitation of platelets for antitumor drug delivery and modulation of the tumor immune microenvironment

Authors :
Jie Guo
Meng-Fei Wang
Yong Zhu
Fumio Watari
Yong-Hong Xu
Xiao Chen
Source :
Acta Materia Medica, Vol 2, Iss 2, Pp 172-190 (2023)
Publication Year :
2023
Publisher :
Compuscript Ltd, 2023.

Abstract

Platelets are blood components traditionally believed to have fundamental roles in vascular hemostasis and thrombosis. In recent years, platelets have received new attention for their roles in tumorigenesis and progression. On the one hand, platelets are actively recruited by various tumors and comprise a crucial part of the tumor microenvironment (TME), thus inspiring the use of platelets for tumor-targeted drug delivery. To this end, various platelet-based devices have been proposed, such as natural platelets, engineered platelets, platelet membranes, and platelet-derived microparticles. On the other hand, platelets are involved in tumor immunosuppression mechanisms, by directing and/or assisting various tumor-associated immune cells. However, in the context of inflammation and autoimmune diseases, platelets can amplify immune responses by promoting immune cell mobilization and activation, thereby exacerbating tissue damage. Thus, interest is growing in the use of tumor-associated platelets as targets for therapeutic modulation of the TME and augmenting anti-tumor immune responses. In this review, we summarize current advances in exploiting platelets for both antitumor drug delivery and immune modulation of the TME.

Details

Language :
English
ISSN :
27377946
Volume :
2
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Acta Materia Medica
Publication Type :
Academic Journal
Accession number :
edsdoj.b9ebdee04d442f9f1a96f842d580f4
Document Type :
article
Full Text :
https://doi.org/10.15212/AMM-2023-0005