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Genome-wide deposition of 6-methyladenine in human DNA reduces the viability of HEK293 cells and directly influences gene expression

Authors :
Julian Broche
Anja R. Köhler
Fiona Kühnel
Bernd Osteresch
Thyagarajan T. Chandrasekaran
Sabrina Adam
Jens Brockmeyer
Albert Jeltsch
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Global introduction of m6dA into human DNA in HEK293 cells reduces their viability and directly alters their gene expression.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.b9e30ba2fc414d7e9ae5e09b21c4e6d7
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04466-1