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Multi-Source Domain Adaptation Techniques for Mitigating Batch Effects: A Comparative Study

Authors :
Rohan Panda
Sunil Vasu Kalmady
Russell Greiner
Source :
Frontiers in Neuroinformatics, Vol 16 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

The past decade has seen an increasing number of applications of deep learning (DL) techniques to biomedical fields, especially in neuroimaging-based analysis. Such DL-based methods are generally data-intensive and require a large number of training instances, which might be infeasible to acquire from a single acquisition site, especially for data, such as fMRI scans, due to the time and costs that they demand. We can attempt to address this issue by combining fMRI data from various sites, thereby creating a bigger heterogeneous dataset. Unfortunately, the inherent differences in the combined data, known as batch effects, often hamper learning a model. To mitigate this issue, techniques such as multi-source domain adaptation [Multi-source Domain Adversarial Networks (MSDA)] aim at learning an effective classification function that uses (learned) domain-invariant latent features. This article analyzes and compares the performance of various popular MSDA methods [MDAN, Domain AggRegation Networks (DARN), Multi-Domain Matching Networks (MDMN), and Moment Matching for MSDA (M3SDA)] at predicting different labels (illness, age, and sex) of images from two public rs-fMRI datasets: ABIDE 1and ADHD-200. It also evaluates the impact of various conditions such as class imbalance, the number of sites along with a comparison of the degree of adaptation of each of the methods, thereby presenting the effectiveness of MSDA models in neuroimaging-based applications.

Details

Language :
English
ISSN :
16625196
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neuroinformatics
Publication Type :
Academic Journal
Accession number :
edsdoj.b9cdb046477e43cd8fa658f8fb3e527b
Document Type :
article
Full Text :
https://doi.org/10.3389/fninf.2022.805117