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A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
- Source :
- Bioactive Materials, Vol 8, Iss , Pp 559-572 (2022)
- Publication Year :
- 2022
- Publisher :
- KeAi Communications Co., Ltd., 2022.
-
Abstract
- We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fibrous scaffold's dimensional maintenance. We further utilized fish collagen to modify the PLGA shell layer (PFC) of coaxial fibers and loaded baicalin (BA) into the PCL core layer (PCL-BA) to endow fibrous scaffold with more functional biological cues. The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype. Importantly, the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation, favor neovascularization and bone formation. This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration.
Details
- Language :
- English
- ISSN :
- 2452199X
- Volume :
- 8
- Issue :
- 559-572
- Database :
- Directory of Open Access Journals
- Journal :
- Bioactive Materials
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b987c41d73949f58ee6f624546c5d2d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bioactmat.2021.06.028