Back to Search
Start Over
Chronic myeloid leukemia (CML): prognostic factors and survival analysis
- Source :
- São Paulo Medical Journal, Vol 114, Iss 1, Pp 1083-1090
- Publisher :
- Associação Paulista de Medicina.
-
Abstract
- The prognostic value of different factors upon diagnosis of CML was analysed in 45 Philadelphia (Ph1)-positive patients. The median survival was 48 months. Univariate analysis showed 5 poor prognostic factors (male sex, under 45 years-old, bone marrow blasts greater than or equal to 10 percent, blood basophils greater than or equal to 6 percent and blood eosinophils greater than or equal to 6 percent) which provided for the development of a clinical staging system: Stage I with none or one factor and a two-year survival rate of 100 percent; Stage II with two or three factors and two-year survival of 72.2 percent; and Stage III with four or five factors and two-year survival of 0 percent (p = 0.00016). Multivariate survival analysis showed that combination of blood basophilia and bone marrow blasts had the strongest predictive relationship to survival time. We conclude that a combination of pretreatment factors identifies different risk subcategories in CML patients and is helpful in assessing the overall prognosis and the treatment approach.
- Subjects :
- Chronic Myeloid Leukemia
Philadelphia Chromosome
Prognosis
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 18069460 and 15163180
- Volume :
- 114
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- São Paulo Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b97beedec2354325b5f95d0cbea10fe2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S1516-31801996000100005