Time varying analysis of dynamic resting-state functional brain network to unfold memory function

Recent advances in brain network analysis are largely based on graph theory methods to assess brain network organization, function, and malfunction. Although, functional magnetic resonance imaging (fMRI) has been frequently used to study brain activity, however, the nonlinear dynamics in resting-state (fMRI) data have not been extensively characterized. In this work, we aim to model the dynamics of resting-state (fMRI) and characterize the dynamical patterns in resting-state (fMRI) time series data in left and right hippocampus and inferior frontal gyrus. We use Sliding Window Embedding (SWE) method to reconstruct the phase space of resting-state (fMRI) data from left and right hippocampus and orbital part of inferior frontal gyrus. The complexity of resting-state MRI data is examined using fractal analysis. The main purpose of the current study is to explore the topological organization of hippocampus and frontal gyrus and consequently, memory. By constructing resting-state functional network from resting-state (fMRI) time series data, we are able to draw a big picture of how brain functions and step forward to classify brain activity between normal control people and patients with different brain disorders.