Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis

Authors :: Pedro Paulo Vasconcellos Varella
Joselita Ferreira Carvalho Santiago
Henrique Carrete Jr.
Elisa Mieko Suemitsu Higa
Elza Márcia Targas Yacubian
Ricardo Silva Centeno
Luís Otávio Sales Ferreira Caboclo
Eduardo Ferreira de Castro Neto
Mauro Canzian
Débora Amado
Esper Abrão Cavalheiro
Maria da Graça Naffah- Mazzacoratti
Source :: Arquivos de Neuro-Psiquiatria, Vol 69, Iss 1, Pp 91-99 (2011)
Publication Year :: 2011
Publisher :: Academia Brasileira de Neurologia (ABNEURO), 2011.
Abstract: We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p

Subjects :: sinal hipocampal em FLAIR
citocinas
NO
glutamato
esclerose hipocampal
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571

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