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Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy
- Source :
- Mediators of Inflammation, Vol 2011 (2011)
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide additive benefit has opened up a new chapter in therapeutic strategy and provides a basis for the development of an innovative approach for the prevention and treatment of ALI/ARDS.
Details
- Language :
- English
- ISSN :
- 09629351 and 14661861
- Volume :
- 2011
- Database :
- Directory of Open Access Journals
- Journal :
- Mediators of Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b8a58b63ff64687a001ea6dd49b3526
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2011/560194