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Independent Effects of HIV and Antiretroviral Therapy on the Oral Microbiome Identified by Multivariate Analyses

Authors :
Clifford J. Beall
Elizabeth A. Lilly
Carolina Granada
Kelly Treas
Kenneth R. Dubois
Shahr B. Hashmi
Jose A. Vazquez
Michael E. Hagensee
Ann L. Griffen
Eugene J. Leys
Paul L. Fidel
Source :
mBio, Vol 14, Iss 3 (2023)
Publication Year :
2023
Publisher :
American Society for Microbiology, 2023.

Abstract

ABSTRACT The oral microbiome is an important predictor of health and disease. We recently reported significant yet modest effects of HIV under highly active antiretroviral therapy (ART) on the oral microbiome (bacterial and fungal) in a large cohort of HIV-positive (HIV+) and matched HIV-negative (HIV−) individuals. As it was unclear whether ART added to or masked further effects of HIV on the oral microbiome, the present study aimed to analyze the effects of HIV and ART independently, which also included HIV− subjects on preexposure prophylaxis (PrEP) therapy. Cross-sectional analyses of the effect of HIV devoid of ART (HIV+ ART− versus matched HIV− subjects) showed a significant effect on both the bacteriome and mycobiome (P

Details

Language :
English
ISSN :
21507511
Volume :
14
Issue :
3
Database :
Directory of Open Access Journals
Journal :
mBio
Publication Type :
Academic Journal
Accession number :
edsdoj.b89b5da7553a4514bb7d14cad1146e64
Document Type :
article
Full Text :
https://doi.org/10.1128/mbio.00409-23