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Comparable Outcomes in Early Hepatocellular Carcinomas Treated with Trans-Arterial Chemoembolization and Radiofrequency Ablation

Authors :
Benjamin Wei Rong Tay
Daniel Q. Huang
Muthiah Mark
Neo Wee Thong
Lee Guan Huei
Lim Seng Gee
Low How Cheng
Lee Yin Mei
Prem Thurairajah
Lim Jia Chen
Cheng Han Ng
Wen Hui Lim
Darren Jun Hao Tan
Da Costa Maureen
Kow Wei Chieh Alfred
Iyer Shridar Ganpathi
Tan Poh Seng
Dan Yock Young
Source :
Biomedicines, Vol 10, Iss 10, p 2361 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The guidelines recommend radiofrequency ablation (RFA) for early hepatocellular carcinomas that are less than 3 cm and trans-arterial chemoembolization (TACE) for intermediate-stage tumors. Real-world patient and tumor factors commonly limit strict adherence to the guidelines. We aimed to compare the clinical outcomes for TACE and RFA in early HCC. All consecutive patients from 2010 to 2014 that were treated with locoregional therapy at our institution were enrolled. The decision for TACE or RFA was based on tumor location, stage and technical accessibility for ablation. A subgroup analysis was performed for patients with tumors less than 3 cm. A total of 168 patients underwent TACE while 56 patients underwent RFA. Patients treated with TACE and RFA had 1- and 5-year survival rates of 84.7% and 39.8% versus 91.5% and 51.5%, respectively (p = 0.28). In tumors less than 3 cm, there was no significant difference in overall survival (p = 0.69), time to progression (p = 0.55), or number of treatment sessions required (p = 0.12). Radiofrequency ablation had a significantly higher chance of a complete response (p = 0.004). In conclusion, TACE may be selectively considered for early-stage hepatocellular carcinoma in patients unsuitable for other modalities.

Details

Language :
English
ISSN :
10102361 and 22279059
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.b89437e2045474e9f8d57f54b2f3f1a
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10102361