Back to Search
Start Over
Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules
- Source :
- Acta Cirúrgica Brasileira, Vol 39 (2024)
- Publication Year :
- 2024
- Publisher :
- Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2024.
-
Abstract
- ABSTRACT Purpose: Bioactive molecules are relevant to fight cancer and associated conditions. Quinoxaline is a privileged N-heterocycle, notably as anticancer agents. Herein, we report the evaluation of the quinoxaline derivatives DEQX and OAQX as anticancer agents, as well as in function of their anti-inflammatory and analgesic activities. Methods: Quinoxalines were synthesized and tested as anticancer agents based on cell viability and Annexin V-FITC apoptosis. Anti-inflammatory activity was evaluated from mouse carrageenan peritonitis and levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-alfa for enzyme-linked immunosorbent assay. Hot-plate and acetic acid-induced writing test were employed to investigate analgesia. Results: Both reduced the Ht-29 cell viability in a dependent-concentration manner (p < 0.001). Total apoptosis was detected for cells treated with 12.5 and 25 µg/mL of both the compounds for 24 and 48 h (all doses, p < 0.0001). DEQX (all doses, p < 0.01) and OAQX (all doses, p < 0.001) acted in leukocyte migration and decreased the IL-1β and TNF-β levels (p < 0.05). DEQX (all doses, p < 0.05) and OAQX (5mg/kg, p < 0.001) showed peripheral analgesic effect. Conclusions: In-vitro and in-vivo results suggest that these quinoxalines are promising for application in pharmacological area due to their anticancer, anti-inflammatory, and peripheric analgesia.
- Subjects :
- Quinoxalines
Apoptosis
Inflammation
Analgesia
Surgery
RD1-811
Subjects
Details
- Language :
- English
- ISSN :
- 16782674
- Volume :
- 39
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Cirúrgica Brasileira
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b88ad78b5d2145a6a2aa610aef110a78
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/acb395124