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Effect of Portulaca oleracea L. on Lowering Uric Acid and Protecting Kidney

Effect of Portulaca oleracea L. on Lowering Uric Acid and Protecting Kidney

Authors :
Youwei LV
Yuchen PAN
Mingjian SUN
Hang YAO
Manli WANG
Peige DU
Liping AN
Source :
Shipin gongye ke-ji, Vol 43, Iss 2, Pp 354-359 (2022)
Publication Year :
2022
Publisher :
The editorial department of Science and Technology of Food Industry, 2022.

Abstract

Objective: To study the uric acid-lowering and renal protective effects of Portulaca oleracea to provide reference for clinical research. Methods: Male ICR mice were randomly divided into 5 groups. Blank group (CON), model group (HUA), allopurinol positive drug control group (ALLOP, 0.02 g/kg/d), purslane high-dose group (PO-H, 1.48 g/kg/d), Portulaca low-dose group (PO-L, 0.5 g/kg/d). Each group was given the corresponding dose for 21 d continuously, starting from the 7th day, except for the blank group, each group was intraperitoneally injected with hypoxanthine (HX, 0.3 g/kg) combined with potassium oxazine (OAPS, 0.3 g/kg) to establish a hyperuricemia model. Observe serum uric acid (SUA) and malondialdehyde (MDA) levels in mice, collect liver to detect xanthine oxidase (XOD) and superoxide dismutase (SOD) levels, collect kidney to detect glutathione (GSH), glutathione peroxidase (GSH-PX) level. 24 hours urine was collected the day before the end of the experiment to detect urine uric acid (UUA) and urine creatinine (UCr) levels, pathological observation of mouse kidney HE staining was performed. Results: Compared with the CON group, the HUA group significantly (P

Details

Language :
Chinese
ISSN :
10020306
Volume :
43
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Shipin gongye ke-ji
Publication Type :
Academic Journal
Accession number :
edsdoj.b884bf71dd744b829bdf6eeafba74779
Document Type :
article
Full Text :
https://doi.org/10.13386/j.issn1002-0306.2021040074