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Circulating T Cell Subsets in Type 1 Diabetes
Circulating T Cell Subsets in Type 1 Diabetes
- Source :
- Cells, Vol 14, Iss 1, p 48 (2025)
- Publication Year :
- 2025
- Publisher :
- MDPI AG, 2025.
-
Abstract
- Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies.
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b8849db941644c8686278ff8cf259293
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cells14010048