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Circulating T Cell Subsets in Type 1 Diabetes

Circulating T Cell Subsets in Type 1 Diabetes

Authors :
Aldo Ferreira-Hermosillo
Paola Santana-Sánchez
Ricardo Vaquero-García
Manuel R. García-Sáenz
Angélica Castro-Ríos
Adriana K. Chávez-Rueda
Rita A. Gómez-Díaz
Luis Chávez-Sánchez
María V. Legorreta-Haquet
Source :
Cells, Vol 14, Iss 1, p 48 (2025)
Publication Year :
2025
Publisher :
MDPI AG, 2025.

Abstract

Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies.

Details

Language :
English
ISSN :
20734409
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.b8849db941644c8686278ff8cf259293
Document Type :
article
Full Text :
https://doi.org/10.3390/cells14010048