Impact of rapid lactate clearance as an indicator of hemodynamic optimization on outcome in out-of-hospital cardiac arrest: A retrospective analysis.

OBJECTIVE:We analyzed the impact of rapid lactate clearance as an indicator of hemodynamic optimization on the outcome of out-of-hospital cardiac arrest (OHCA) during early post-cardiac arrest care (PCAC). METHODS:This retrospective analysis was based on a prospective cohort. We selected adult patients with OHCA who achieved a survival event between May 2006 and December 2017. Serum lactate levels were measured at 0 and 6 h after a survival event. The lactate clearance rate was calculated as (lactate at 0 h-lactate at 6 h)/lactate at 0 h. The threshold lactate clearance value for predicting survival to discharge was determined by receiver operating characteristic (ROC) curve analysis. Rapid lactate clearance was defined as the lactate clearance above the threshold value or normalization of serum lactate level (