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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Authors :
Heming Wang
Jacqueline M. Lane
Samuel E. Jones
Hassan S. Dashti
Hanna M. Ollila
Andrew R. Wood
Vincent T. van Hees
Ben Brumpton
Bendik S. Winsvold
Katri Kantojärvi
Teemu Palviainen
Brian E. Cade
Tamar Sofer
Yanwei Song
Krunal Patel
Simon G. Anderson
David A. Bechtold
Jack Bowden
Richard Emsley
Simon D. Kyle
Max A. Little
Andrew S. Loudon
Frank A. J. L. Scheer
Shaun M. Purcell
Rebecca C. Richmond
Kai Spiegelhalder
Jessica Tyrrell
Xiaofeng Zhu
Christer Hublin
Jaakko A. Kaprio
Kati Kristiansson
Sonja Sulkava
Tiina Paunio
Kristian Hveem
Jonas B. Nielsen
Cristen J. Willer
John-Anker Zwart
Linn B. Strand
Timothy M. Frayling
David Ray
Deborah A. Lawlor
Martin K. Rutter
Michael N. Weedon
Susan Redline
Richa Saxena
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmentation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b82094d6f1747f6b19a7f7da87c85b4
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11456-7