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Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Authors :
Zhe Zhao
Huimeng Wang
Mai Shi
Tianyuan Zhu
Troi Pediongco
Xin Yi Lim
Bronwyn S. Meehan
Adam G. Nelson
David P. Fairlie
Jeffrey Y. W. Mak
Sidonia B. G. Eckle
Marcela de Lima Moreira
Carolin Tumpach
Michael Bramhall
Cameron G. Williams
Hyun Jae Lee
Ashraful Haque
Maximilien Evrard
Jamie Rossjohn
James McCluskey
Alexandra J. Corbett
Zhenjun Chen
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b7dc772b44d4a1993581d2bb0169b5d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24570-2